Author

T. Sakaue

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:statistical model· 2 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

H. Schiessel· 2 shared T. YAMAMOTO· 2 shared H. Onji· 1 shared J. Murai· 1 shared N. Onishi· 1 shared S. Higashiyama· 1 shared S. Tate· 1 shared T. Matsumoto· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 22 mutual co-author links

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2 shared papersBiophysics

H. Schiessel

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Author profile →

3 papers

Recent·Most cited

Synergistic effects of PARP inhibitors by Schlafen 11 and BRCA2-deficiency through accumulation of single-strand DNA gaps behind a fork

H. Onji, S. Tate, T. Sakaue, N. Onishi, T. Matsumoto, T. Sugiyama, S. Higashiyama, J. Murai

This paper shows that SLFN11 and BRCA2-deficiency together increase PARP inhibitor sensitivity by enhancing ssDNA gap accumulation behind replication forks.

bioRxiv · Jun 28, 2023 · PreprintCancer Biology

Slow chromatin dynamics enhances promoter accessibility to transcriptional condensates

T. YAMAMOTO, T. SAKAUE, H. Schiessel

The paper theoretically studies chromatin dynamics driven by loop extrusion to show that longer linker DNA increases promoter contact probability with transcriptional condensates when loop extrusion is active.

bioRxiv · Feb 16, 2021Biophysics

Phase separation of chromatin brush driven by enzymatic reaction dynamics of histone posttranslational modifications

T. YAMAMOTO, T. Sakaue, H. Schiessel

This study models chromatin phase separation in a chromatin brush system, showing that it occurs when the brush height drops below a threshold due to anti-correlation between activators and silencers.

bioRxiv · Nov 30, 2020 · PreprintBiophysics