Author

S. Higashiyama

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

J. Murai· 2 shared A. Ueda· 1 shared E. Miyoshi· 1 shared H. H. Freeze· 1 shared H. Mori· 1 shared H. Onji· 1 shared H. Tahara· 1 shared H. Udono· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

J. Murai

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Synergistic effects of PARP inhibitors by Schlafen 11 and BRCA2-deficiency through accumulation of single-strand DNA gaps behind a fork

H. Onji, S. Tate, T. Sakaue, N. Onishi, T. Matsumoto, T. Sugiyama, S. Higashiyama, J. Murai

This paper shows that SLFN11 and BRCA2-deficiency together increase PARP inhibitor sensitivity by enhancing ssDNA gap accumulation behind replication forks.

bioRxiv · Jun 28, 2023 · PreprintCancer Biology

Metabolic clogging of mannose triggers genomic instability via dNTP loss in human cancer cells

Y. Harada, Y. Mizote, T. Suzuki, M. Nishida, T. Hiratsuka, A. Ueda, Y. Imagawa, K. Maeda, Y. Ohkawa, J. Murai, H. H. Freeze, E. Miyoshi, S. Higashiyama, H. Udono, N. Dohmae, , N. Taniguchi

This study shows that excess mannose causes dNTP depletion, leading to genomic instability and enhanced sensitivity to chemotherapy in cancer cells.

bioRxiv · Oct 17, 2022Cancer Biology

Highly concentrated trehalose induces transient senescence-associated secretory phenotype in fibroblasts via CDKN1A/p21

J. Muto, S. Fukuda, K. Watanabe, X. Dai, T. Tsuda, T. Kiyoi, H. Mori, K. Shiraishi, M. Murakami, S. Higashiyama, Y. Mizukami, K. Sayama

High-concentration trehalose induces a beneficial senescence-associated secretory phenotype in fibroblasts via CDKN1A/p21, enhancing wound repair in mice.

bioRxiv · Oct 6, 2021 · PreprintCell Biology

Aberrant accumulation of NIK promotes tumorigenicity by dysregulating post-translational modifications in breast cancer

Y. Hayashi, J. Nakayama, M. Yamamoto, M. Maekawa, S. Watanabe, S. Higashiyama, J.-i. Inoue, Y. Yamamoto, K. Semba

This study identifies NIK upregulation in breast cancer due to translational dysregulation, which promotes tumorigenicity by activating the non-canonical NF-κB pathway.

bioRxiv · Aug 27, 2021 · PreprintCancer Biology