T. Matsumoto

Enrichment of allelic editing outcomes by Prime Editing in iPS cells

This study compares Cas9 and Prime Editing (PE) in human iPS cells, showing PE's superior precision and demonstrating how sorting by PE expression affects allelic editing outcomes.

Development of a metabolic engineering technology to simultaneously suppress the expression of multiple genes in yeast and application in carotenoid production

The paper develops a metabolic engineering technology to suppress multiple genes in yeast and applies it to enhance carotenoid production.

Highly efficient transgenic mouse production using piggyBac and its application to rapid phenotyping at the founder generation

This study improves transgenic mouse production efficiency using piggyBac, enabling phenotyping in the founder generation and demonstrating application with bacterial artificial chromosome transgenes.

Improvement of cell growth in green algae Chlamydomonas reinhardtii through co-cultivation with yeast Saccharomyces cerevisiae

This study improves the growth of green algae Chlamydomonas reinhardtii by co-cultivating it with yeast Saccharomyces cerevisiae, finding that a 1:3 inoculum ratio enhances cell concentration by 1.5 times.

Synergistic effects of PARP inhibitors by Schlafen 11 and BRCA2-deficiency through accumulation of single-strand DNA gaps behind a fork

This paper shows that SLFN11 and BRCA2-deficiency together increase PARP inhibitor sensitivity by enhancing ssDNA gap accumulation behind replication forks.

An ancient ecospecies of Helicobacter pylori found in Indigenous populations and animal adapted lineages.

The paper identifies a new ecospecies of Helicobacter pylori, 'Hardy', found in Indigenous populations and animal-adapted lineages, with distinct genetic features and evolutionary history.

Arabidopsis thaliana subclass I ACTIN DEPOLYMERIZING FACTORs regulate nuclear organization and gene expression

This study shows subclass I ADFs in Arabidopsis regulate nuclear organization and gene expression, affecting chromocenter size and NLR gene expression.

Fc-modified SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models.

The paper develops Fc-modified SARS-CoV-2 neutralizing antibodies effective against variants, showing reduced viral titers and lung damage in animal models.

Microscopic characterization of local strain field in healing tissue in the central third defect of mouse patellar tendon at early-phase of healing

This study measures the microscopic strain field in healing mouse patellar tendon tissue to assess mechanical stimulus effects on cell behavior and tissue recovery.

Genome-wide association study of gastric cancer- and duodenal ulcer-derived Helicobacter pylori strains reveals discriminatory amino acid differences and novel oncoprotein candidates

This study uses GWAS to identify genetic variations in H. pylori strains associated with gastric cancer and duodenal ulcers, revealing amino acid differences and novel oncoprotein candidates.

APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expression

The paper develops APOBEC3B reporter myeloma cell lines to study DNA damage response pathways that regulate APOBEC3B expression, finding that conventional therapies increase its expression while targeted drugs do not.

Evaluation of the impact of seasonal variations in photoperiod on the hepatic metabolism of medaka (Oryzias latipes)

This study examines how short-day photoperiod affects hepatic lipid metabolism in medaka, showing increased fatty acid accumulation and altered metabolic pathways.

Frequent Non-random Shifts in the Temporal Sequence of Developmental Landmark Events during Teleost Evolutionary Diversification

This study analyzes the evolutionary changes in developmental sequences across 31 teleost species, finding frequent non-random shifts in the timing of developmental landmark events.