T. T. Vo

Cytosolic bacterial pathogens activate TLR pathways in tumors that synergistically enhance STING agonist cancer therapies

This study shows that combining STING and TLR agonists enhances anti-tumor effects in mice, with synergistic responses observed when using bacterial pathogens and small molecule TLR agonists.

Host glutathione is required for Rickettsia parkeri to properly septate, avoid ubiquitylation, and survive in macrophages.