Essential role of an acidic endosomal environment in JAK3-mediated signal transduction
Y. Amano, N. Tanaka, T. Takeshita, K. Kojima
This study shows that acidic endosomal environments are essential for JAK3-mediated signal transduction and that IAVNs like chloroquine and monensin disrupt this process, affecting cytokine signaling and arthritis.
bioRxiv · Sep 7, 2023 · PreprintImmunology