Author

T. Trian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 2 Physiology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

P. Berger· 5 shared E. Maurat· 4 shared I. Dupin· 4 shared M. Thumerel· 4 shared H. Begueret· 3 shared M. Zysman· 3 shared P. Esteves· 3 shared P. Henrot· 3 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersPhysiology

P. Berger

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A novel in vitro tubular model to recapitulate features of distal airways: The bronchioid

E. Maurat, K. Raasch, A. M. Leipold, P. Henrot, M. Zysman, R. Prevel, T. Trian, T. Krammer, V. Bergeron, M. Thumerel, P. Nassoy, P. Berger, A.-E. Saliba, L. Andrique, G. Recher, I. Dupin

The paper introduces a bronchioid model using human bronchial stem cells in an alginate scaffold to mimic distal airway structure and function, showing ciliary activity and pathophysiological features.

bioRxiv · Dec 6, 2023 · PreprintPhysiology

CXCR4 blockade alleviates pulmonary and cardiac outcomes in early COPD

I. Dupin, P. Henrot, E. Maurat, R. Abohalaka, S. Chaigne, D. El Hamrani, E. Eyraud, R. Prevel, P. Esteves, M. Campagnac, M. Dubreuil, G. Cardouat, C. Bouchet, O. Ousova, J.-W. Dupuy, , P. Berger

This study shows that blocking CXCR4 improves lung and cardiac outcomes in early COPD using both human samples and mouse models.

bioRxiv · Mar 10, 2023Pathology

Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response

E. Eyraud, E. Maurat, J.-M. Sac-Epee, P. Henrot, M. Zysman, P. Esteves, T. Trian, J.-W. Dupuy, A. Leipold, A.-E. Saliba, H. Begueret, P.-O. Girodet, M. Thumerel, R. Hustache-Castaing, R. Marthan, , I. Dupin

The paper investigates interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammation, showing increased proximity and functional effects in COPD patients.

bioRxiv · Oct 21, 2022Pathology

SARS-CoV-2 transmission via apical syncytia release from primary bronchial epithelia and infectivity restriction in children epithelia

G. Beucher, M.-L. Blondot, A. Celle, N. Pied, P. Recordon-Pinson, P. Esteves, M. Faure, M. Metifiot, S. Lacomme, D. Dacheaux, D. R. Robinson, G. Laengst, F. Beaufils, M.-E. Lafon, P. Berger, , H. Wodrich

This study shows that adult bronchial epithelia form infectious syncytia releasing SARS-CoV-2, while children's epithelia resist infection due to faster interferon response.

bioRxiv · May 28, 2021Microbiology

Fibrocyte accumulation in bronchi: a cellular hallmark of COPD

I. Dupin, M. Thumerel, E. Maurat, F. Coste, H. Begueret, T. Trian, M. Montaudon, R. Marthan, P.-O. Girodet, P. Berger

This study quantifies fibrocyte density in bronchial tissue of COPD patients and controls, finding increased fibrocytes associated with reduced lung function and increased bronchial wall thickness.

bioRxiv · Oct 23, 2018 · PreprintPhysiology