P. Berger

Primary Human Neutrophils and Monocytes/Macrophages Migrate along Endothelial Cell Boundaries to Optimize Search Efficiency

This study shows immune cells enhance search efficiency by migrating along endothelial cell boundaries, increasing sampled cells per distance and chemokine sensitivity.

A novel in vitro tubular model to recapitulate features of distal airways: The bronchioid

The paper introduces a bronchioid model using human bronchial stem cells in an alginate scaffold to mimic distal airway structure and function, showing ciliary activity and pathophysiological features.

CXCR4 blockade alleviates pulmonary and cardiac outcomes in early COPD

This study shows that blocking CXCR4 improves lung and cardiac outcomes in early COPD using both human samples and mouse models.

Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response

The paper investigates interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammation, showing increased proximity and functional effects in COPD patients.

SARS-CoV-2 transmission via apical syncytia release from primary bronchial epithelia and infectivity restriction in children epithelia

This study shows that adult bronchial epithelia form infectious syncytia releasing SARS-CoV-2, while children's epithelia resist infection due to faster interferon response.

Paladin is a PI(4,5)P2 phosphoinositide phosphatase that regulates endosomal signaling and angiogenesis

Fibrocyte accumulation in bronchi: a cellular hallmark of COPD

This study quantifies fibrocyte density in bronchial tissue of COPD patients and controls, finding increased fibrocytes associated with reduced lung function and increased bronchial wall thickness.