D. R. Robinson

CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality

This study shows CDK12 loss drives prostate cancer development and identifies CDK13 as a therapeutic target through paralog-based synthetic lethality in CDK12-mutant tumors.

Streptococcus pyogenes Cas9 ribonucleoprotein delivery for efficient, rapid and marker-free gene editing in Trypanosoma and Leishmania

This paper demonstrates a marker-free gene editing method using SpCas9 ribonucleoprotein complexes in trypanosomatids, enabling efficient genetic modifications in various life stages of T. brucei, T. congolense, and Leishmania promastigotes.

Harbingers of Aggressive Prostate Cancer: Precision Oncology Case Studies

This study identifies molecular features of primary prostate cancer and their relation to metastasis using genomic and histopathological analysis.

Intrabody induced cell death by targeting the T. brucei cytoskeletal protein TbBILBO1

The paper demonstrates that an intrabody targeting TbBILBO1 induces cell death in Trypanosoma brucei, mimicking RNAi knockdown effects.

SARS-CoV-2 transmission via apical syncytia release from primary bronchial epithelia and infectivity restriction in children epithelia

This study shows that adult bronchial epithelia form infectious syncytia releasing SARS-CoV-2, while children's epithelia resist infection due to faster interferon response.

Structural and functional studies of the first tripartite protein complex at the Trypanosoma brucei flagellar pocket collar

This study identifies BILBO2 as a new FPC component and characterizes its interaction with BILBO1 and FPC4, revealing a tripartite complex structure and functional domains.

Positional dynamics and glycosomal recruitment of developmental regulators during trypanosome differentiation

The paper tracks TbPIP39 recruitment to glycosomes during trypanosome differentiation and identifies a regulatory site coordinating signaling and glycosomal development.