Evolutionarily-conserved chromatin crosstalk generates a DOT1L-dose dependency in thymic lymphoma caused by loss of HDAC1
H. Vlaming, C. McLean, T. Korthout, M. F. Alemdehy, S. Henriks, C. Lancini, S. Palit, S. Klarenbeek, T. M. Molenaar, L. Hoekman, T. T. Schmidlin, M. Altelaar, T. v. Welsem, J.-H. Dannenberg, H. Jacobs, F. van Leeuwen
The paper identifies an evolutionarily-conserved interaction between HDAC1 and DOT1L that influences H3K79 methylation and contributes to thymic lymphoma development.
bioRxiv · Jan 10, 2019Cell Biology