BiochemistrybioRxiv
Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy
I. Vasiliauskaite - Brooks, R. D. Healey, P. Rochaix…·S. Granier
The paper reports the crystal structure of human ACER3, revealing its intramembrane architecture and explaining Ca2+ and Zn2+ regulation of its enzymatic activity and dysfunction in leukodystrophy.
DOI 10.1038/s41467-018-07864-w