Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy
I. Vasiliauskaite - Brooks, R. D. Healey, P. Rochaix, R. Sounier, C. M. Grison, T. Waltrich - Augusto, M. Fortier, F. Hoh, E. M. Saied, C. Arenz, S. Basu, C. Leyrat, S. Granier
The paper reports the crystal structure of human ACER3, revealing its intramembrane architecture and explaining Ca2+ and Zn2+ regulation of its enzymatic activity and dysfunction in leukodystrophy.
bioRxiv · Jun 15, 2018Biochemistry