Author

R. D. Healey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:structural biology· 2 Research Focus:protein structure prediction· 1

Frequent Co-Authors

C. LEYRAT· 3 shared S. Basu· 3 shared S. Granier· 3 shared C. Arenz· 2 shared X. Cong· 2 shared A. Pica· 1 shared A.-S. Humm· 1 shared C. BECHARA· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersBiochemistry

C. LEYRAT

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3 papers

Recent·Most cited

Discovery and mechanism of action of small molecule inhibitors of ceramidases

S. Granier, R. D. Healey, E. Saied, X. Cong, G. Karsai, L. Gabellier, J. Saint-Paul, E. Del Nero, S. Jeannot, M. Drapeau, S. Fontanel, D. Maurel, S. Basu, C. LEYRAT, G. Bossis, , C. Arenz

The paper discovers small molecule inhibitors of alkaline ceramidase 3 using fluorescent substrates and characterizes their mechanism of action.

bioRxiv · Jun 15, 2021Biochemistry

An automated platform for structural analysis of membrane proteins through serial crystallography

R. D. Healey, S. Basu, A.-S. Humm, C. Leyrat, X. Cong, J. Golebiowski, F. Dupeux, A. Pica, S. Granier, J. A. Marquez

This paper introduces an automated platform for structural analysis of membrane proteins using serial crystallography, enabling high-throughput ligand discovery and structural determination.

bioRxiv · Jun 3, 2021Biochemistry

Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy

I. Vasiliauskaite - Brooks, R. D. Healey, P. Rochaix, R. Sounier, C. M. Grison, T. Waltrich - Augusto, M. Fortier, F. Hoh, E. M. Saied, C. Arenz, S. Basu, C. Leyrat, S. Granier

The paper reports the crystal structure of human ACER3, revealing its intramembrane architecture and explaining Ca2+ and Zn2+ regulation of its enzymatic activity and dysfunction in leukodystrophy.

bioRxiv · Jun 15, 2018Biochemistry