C. Leyrat

Conformational dynamics underlying Atypical Chemokine Receptor 3 activation

This study investigates the conformational dynamics of ACKR3 activation using HDX-MS and molecular dynamics simulations, revealing key structural changes and ligand binding mechanisms.

Structure of the N-RNA/P interface reveals mode of L/P attachment to the nucleocapsid of human metapneumovirus

The paper determines the structure of the N-RNA/P triple complex in human metapneumovirus, revealing how the polymerase attaches to the RNA template and providing a basis for therapeutic design.

Unraveling human, rodent and snake Kolmioviridae replication to anticipate cross-species transmission

This study compares the replication of three Kolmioviridae viruses in vitro and in vivo, revealing differences in host range and replication efficiency.

Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins

This study investigates how Staphylococcus aureus leukotoxins recognize chemokine receptors, identifying sulfotyrosine binding sites and proposing structural models for receptor-toxin interactions.

Discovery and mechanism of action of small molecule inhibitors of ceramidases

The paper discovers small molecule inhibitors of alkaline ceramidase 3 using fluorescent substrates and characterizes their mechanism of action.

An automated platform for structural analysis of membrane proteins through serial crystallography

This paper introduces an automated platform for structural analysis of membrane proteins using serial crystallography, enabling high-throughput ligand discovery and structural determination.

Mechanisms of GPCR hijacking by Staphylococcus aureus

This study investigates how Staphylococcus aureus leukotoxins HlgA and HlgB interact with ACKR1, altering its structure and function to aid bacterial growth and immune evasion.

Structure of the antidiuretic hormone vasopressin receptor signalling complex.

The paper reports the structure of the AVP-V2R-Gs complex using cryo-EM, revealing distinct conformations and a unique receptor-Gs interface that explains genetic disease variants.

Open Science Saves Lives: Lessons from the COVID-19 Pandemic

The paper discusses the adoption and misuse of Open Science principles during the COVID-19 pandemic and advocates for their wider implementation to ensure rigorous and transparent research.

Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy

The paper reports the crystal structure of human ACER3, revealing its intramembrane architecture and explaining Ca2+ and Zn2+ regulation of its enzymatic activity and dysfunction in leukodystrophy.