Author

S. Granier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 8 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 6 Research Focus:protein structure prediction· 3 Approach:statistical model· 3 Assay:cryo-EM· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

C. Leyrat· 7 shared X. Cong· 6 shared R. Sounier· 5 shared C. BECHARA· 4 shared B. Mouillac· 3 shared C. M. Grison· 3 shared E. Del Nero· 3 shared H. Orcel· 3 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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7 shared papersBiochemistry

C. Leyrat

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Conformational dynamics underlying Atypical Chemokine Receptor 3 activation

O. Otun, C. Aljamous, E. Del Nero, M. Arimont-Segura, R. Bosma, B. Zarzycka, T. Girbau, C. Leyrat, C. de Graaf, R. Leurs, T. Durroux, S. Granier, X. Cong, C. BECHARA

This study investigates the conformational dynamics of ACKR3 activation using HDX-MS and molecular dynamics simulations, revealing key structural changes and ligand binding mechanisms.

bioRxiv · Jul 17, 2023 · PreprintBiochemistry

Biased activation of the vasopressin V2 receptor probed by NMR, paramagnetic ligands, and molecular dynamics simulations

G. Gaibelet, A. Fouillen, R. Stephanie, H. Orcel, C. Mendre, A. Kanso, R. Lanotte, J. Nguyen, J. Dimon, S. Urbach, R. Sounier, S. Granier, D. Bonnet, X. Cong, B. Mouillac, H. Demene

The paper uses NMR, molecular dynamics, and pharmacology to study conformational changes in the V2R receptor bound to different ligands, revealing a mechanism for Gs-biased agonism involving TM7 and TM3 interactions.

bioRxiv · Jun 6, 2023 · PreprintBiophysics

Structure of the vasopressin hormone-V2 receptor-β-arrestin1 ternary complex

J. Bous, A. Fouillen, H. Orcel, S. Trapani, X. Cong, S. Fontanel, J. Saint-Paul, J. LAI KEE HIM, S. Urbach, N. Sibille, R. SOUNIER, S. Granier, B. Mouillac, P. Bron

The paper reports the cryo-EM structure of the V2 receptor-{beta}-arrestin1 complex, revealing structural variability in GPCR-arrestin interactions.

bioRxiv · Feb 11, 2022Biochemistry

Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins

C. Leyrat, S. Granier, T. Durroux, C. Bechara, S. Jeannot, F. Peysson, C. M. Grison, P. Verdie, L. Brunel, F. Hoh, X. Cong, O. Otun, P. Lambey

This study investigates how Staphylococcus aureus leukotoxins recognize chemokine receptors, identifying sulfotyrosine binding sites and proposing structural models for receptor-toxin interactions.

bioRxiv · Aug 5, 2021Biochemistry

Discovery and mechanism of action of small molecule inhibitors of ceramidases

S. Granier, R. D. Healey, E. Saied, X. Cong, G. Karsai, L. Gabellier, J. Saint-Paul, E. Del Nero, S. Jeannot, M. Drapeau, S. Fontanel, D. Maurel, S. Basu, C. LEYRAT, G. Bossis, , C. Arenz

The paper discovers small molecule inhibitors of alkaline ceramidase 3 using fluorescent substrates and characterizes their mechanism of action.

bioRxiv · Jun 15, 2021Biochemistry

An automated platform for structural analysis of membrane proteins through serial crystallography

R. D. Healey, S. Basu, A.-S. Humm, C. Leyrat, X. Cong, J. Golebiowski, F. Dupeux, A. Pica, S. Granier, J. A. Marquez

This paper introduces an automated platform for structural analysis of membrane proteins using serial crystallography, enabling high-throughput ligand discovery and structural determination.

bioRxiv · Jun 3, 2021Biochemistry

Mechanisms of GPCR hijacking by Staphylococcus aureus

C. M. Grison, C. Leyrat, P. Lambey, S. Jeannot, E. Del Nero, S. Fontanel, F. Peysson, J. Heuninck, R. Sounier, T. Durroux, S. Granier, C. Bechara

This study investigates how Staphylococcus aureus leukotoxins HlgA and HlgB interact with ACKR1, altering its structure and function to aid bacterial growth and immune evasion.

bioRxiv · Feb 8, 2021 · PreprintBiochemistry

Structure of the antidiuretic hormone vasopressin receptor signalling complex.

J. Bous, H. Orcel, N. Floquet, C. Leyrat, J. Lai-Kee-Him, G. Gaibelet, A. Ancelin, J. Saint-Paul, S. Trapani, M. Louet, R. Sounier, H. Demene, S. Granier, P. Bron, B. Mouillac

The paper reports the structure of the AVP-V2R-Gs complex using cryo-EM, revealing distinct conformations and a unique receptor-Gs interface that explains genetic disease variants.

bioRxiv · Dec 22, 2020 · PreprintBiochemistry

Global phylogenomics of multidrug resistant Salmonella enterica serotype Kentucky ST198

J. Hawkey, S. Le Hello, B. Doublet, S. Granier, R. Hendriksen, W. F. Fricke, P.-J. Ceyssens, C. Gomart, H. Billman-Jacobe, K. E. Holt, F.-X. Weill

This study uses whole-genome sequencing to analyze the global spread and antimicrobial resistance of Salmonella enterica serotype Kentucky ST198, identifying a single clonal lineage responsible for multidrug resistance.

bioRxiv · Feb 3, 2019Microbiology

Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy

I. Vasiliauskaite - Brooks, R. D. Healey, P. Rochaix, R. Sounier, C. M. Grison, T. Waltrich - Augusto, M. Fortier, F. Hoh, E. M. Saied, C. Arenz, S. Basu, C. Leyrat, S. Granier

The paper reports the crystal structure of human ACER3, revealing its intramembrane architecture and explaining Ca2+ and Zn2+ regulation of its enzymatic activity and dysfunction in leukodystrophy.

bioRxiv · Jun 15, 2018Biochemistry