Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation
T. Xin, S. Gallini, D. Gonzalez, L. E. Gonzalez, S. Regot, V. Greco
This study shows that oncogenic KrasG12D causes tissue deformation by converting pulsatile ERK signals into sustained activation, disrupting stem cell coordination in hair follicles.
bioRxiv · Sep 14, 2022Cancer Biology