T. Y. Li

Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation

This study shows lysosomes mediate the mitochondrial UPR through mTORC1-dependent ATF4 phosphorylation, essential for mitochondrial redox homeostasis and cell survival under stress.

A lysosomal surveillance response (LySR) that reduces proteotoxicity and extends healthspan

This paper identifies a lysosomal surveillance response (LySR) that reduces proteotoxicity and extends healthspan in worms and mammalian cells by enhancing protein aggregate clearance.