Author

A. W. Gao

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:C. elegans· 3 Assay:bulk RNA-seq· 2 Assay:metabolomics· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

F. M. Vaz· 2 shared G. E. Janssens· 2 shared J. Auwerx· 2 shared M. van Weeghel· 2 shared Q. Wang· 2 shared R. H. Houtkooper· 2 shared R. L. Smith· 2 shared T. Y. Li· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

F. M. Vaz

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Author profile →

4 papers

Recent·Most cited

Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation

T. Y. Li, Q. Wang, A. W. Gao, X. Li, A. Mottis, M. Shong, J. Auwerx

This study shows lysosomes mediate the mitochondrial UPR through mTORC1-dependent ATF4 phosphorylation, essential for mitochondrial redox homeostasis and cell survival under stress.

bioRxiv · Nov 14, 2022Cell Biology

A lysosomal surveillance response (LySR) that reduces proteotoxicity and extends healthspan

T. Y. Li, A. W. Gao, X. Li, Y. J. Liu, R. N. Arey, K. Morales, A. Lalou, Q. Wang, T. Lima, J. Auwerx

This paper identifies a lysosomal surveillance response (LySR) that reduces proteotoxicity and extends healthspan in worms and mammalian cells by enhancing protein aggregate clearance.

bioRxiv · Jun 13, 2022 · PreprintCell Biology

Reduced ech-6 Expression Attenuates Fat-induced Premature Aging in C. elegans

Y. J. Liu, A. W. Gao, R. L. Smith, G. E. Janssens, D. M. Panneman, A. Jongejan, M. van Weeghel, F. M. Vaz, M. J. Silvestrini, L. R. Lapierre, A. W. MacInnes, R. H. Houtkooper

This study shows that reducing ech-6 expression in C. elegans mitigates fat-induced premature aging, suggesting a role for ech-6 in metabolic flexibility and longevity.

bioRxiv · Nov 2, 2020 · PreprintCell Biology

Metabolomics and lipidomics in C. elegans using a single sample preparation

M. Molenaars, B. V. Schomakers, H. L. Elfrink, A. W. Gao, M. A. T. Vervaart, M. L. Pras-Raves, A. C. Luyf, R. L. Smith, M. G. Sterken, J. E. Kammenga, A. H. C. van Kampen, G. E. Janssens, F. M. Vaz, M. van Weeghel, R. H. Houtkooper

This paper introduces a single-sample preparation method for comprehensive metabolomics and lipidomics in C. elegans, enabling semi-quantitative analysis of over 100 polar metabolites and over 1000 apolar metabolites.

bioRxiv · Jul 6, 2020Biochemistry