Author

I. Ayala

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Physiology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:protein folding & dynamics· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

C. E. Shannon· 2 shared C. Laguri· 2 shared J.-P. Simorre· 2 shared K. Giandoreggio-Barranco· 2 shared L. Norton· 2 shared N. R. Skrynnikov· 2 shared P. Schanda· 2 shared A. Colanzi· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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2 shared papersPhysiology

C. E. Shannon

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Sex-dependent adipose glucose partitioning by the mitochondrial pyruvate carrier

C. E. Shannon, T. Bakewell, M. J. Fourcaudot, I. Ayala, G. Romero, M. Asmis, L. C. Freitas Lima, M. Wallace, L. Norton

This study investigates the role of the mitochondrial pyruvate carrier (MPC) in adipose glucose partitioning, finding sex-dependent effects on triglyceride synthesis and metabolic adaptation in mice.

bioRxiv · May 11, 2024 · PreprintPhysiology

The Golgi checkpoint: Golgi unlinking during G2 is required for correct spindle formation and cytokinesis

F. Mascanzoni, I. Ayala, R. Iannitti, A. Luini, A. Colanzi

The paper shows that Golgi unlinking during G2 is essential for proper spindle formation and cytokinesis, as disrupting this process leads to mitotic defects and increased cell transformation risk.

bioRxiv · Mar 5, 2023 · PreprintCell Biology

The unique three-dimensional arrangement of Macrophage Galactose Lectin enables E. coli LipoPolySaccharides recognition through two distinct interfaces

M. Abbas, M. Maalej, F. Nieto Fabregat, M. Thepaut, J.-p. Kleman, I. Ayala, A. Molinaro, J.-P. Simorre, R. Marchetti, F. Fieschi, C. Laguri

The paper identifies two distinct glycan binding interfaces on Macrophage Galactose Lectin that enable high-affinity recognition of E. coli LipoPolySaccharides, independent of the canonical calcium-dependent site.

bioRxiv · Mar 2, 2023 · PreprintBiophysics

Aromatic ring flips in differently packedubiquitin protein crystals from MAS NMR andMD

D. F. Gauto, O. O. Lebedenko, L. M. Becker, I. Ayala, R. Lichtenecker, N. R. Skrynnikov, P. Schanda

The paper investigates how crystal packing affects aromatic ring flips in ubiquitin using NMR and MD simulations, finding that intramolecular factors dominate over packing effects.

bioRxiv · Jul 7, 2022Biophysics

Persistent Inflammatory Lipotoxicity Impedes Pancreatic β-cell Function in Diet-Induced Obese Mice Despite Correction of Glucotoxicity

I. A. Valdez, J. P. Palavicini, T. M. Bakewell, M. Fourcaudot, I. Ayala, Z. Xu, A. Khattab, X. Han, C. E. Shannon, L. Norton

This study shows that even after correcting hyperglycemia, persistent lipotoxicity from arachidonic acid and lysophosphatidylcholine impairs β-cell function in diet-induced obese mice.

bioRxiv · May 31, 2022 · PreprintPhysiology

LptB2FG is an ABC transporter with Adenylate Kinase activity regulated by LptC/A recruitment

T. Baeta, K. Giandoreggio-Barranco, I. Ayala, E. C. Moura, P. Sperandeo, A. Polissi, J.-P. Simorre, C. Laguri

The paper characterizes LptB2FG as an ABC transporter with Adenylate Kinase activity regulated by interactions with LptC/A partners.

bioRxiv · Jul 8, 2021 · PreprintBiochemistry

Mitochondrial cytochrome c liberates the nucleophosmin-sequestered ARF tumor suppressor in the nucleolus

K. Gonzalez-Arzola, A. Diaz-Quintana, N. Bernardo-Garcia, M. A. Casado-Combreras, C. A. Elena-Real, A. Velazquez-Cruz, S. Gil-Caballero, A. Velazquez-Campoy, E. Szulc, I. Ayala, R. Arranz, X. Salvatella, J. M. Valpuesta, J. A. Hermoso, M. A. De la Rosa, I. Diaz-Moreno

This study identifies mitochondrial cytochrome c as a factor that releases ARF tumor suppressor from NPM sequestration in the nucleolus upon DNA damage.

bioRxiv · May 7, 2020 · PreprintBiophysics

NMR reveals light-induced changes in the dynamics of a photoswitchable fluorescent protein

B. Brutscher, N. E. Christou, I. Ayala, K. Giandoreggio-Barranco, M. Byrdin, V. Adam, D. Bourgeois

This study uses NMR to investigate light-induced conformational dynamics of rsFolder, a photoswitchable fluorescent protein, revealing dynamic changes that could inform future mutagenesis efforts.

bioRxiv · Jul 3, 2019Biophysics

Slow conformational exchange and overall rocking motion in ubiquitin protein crystals

V. Kurauskas, S. A. Izmailov, O. N. Rogacheva, A. Hessel, I. Ayala, J. Woodhouse, A. Shilova, Y. Xue, T. Yuwen, N. Coquelle, J.-P. Colletier, N. R. Skrynnikov, P. Schanda

This study investigates how crystal packing affects microsecond dynamics of ubiquitin using solid-state NMR and MD simulations, revealing altered thermodynamics and kinetics of conformational exchange.

bioRxiv · Jun 2, 2017Biophysics