Endothelial Rbpj is essential for the education of tumour-associated macrophages
R. Mülfarth, E. Alsina-Sanchis, I. Moll, S. Böhn, L. Wiedmann, L. Jordana Urriza, T. Ziegelbauer, J. Taylor, F. De Angelis Rigotti, A. Stögbauer, B. D. Giaimo, A. Cerwenka, T. Borggrefe, A. Fischer, J. Rodriguez-Vita
This study shows that endothelial Rbpj promotes TAM education in EOC by regulating CXCL2, which drives CD44 expression and cholesterol depletion in TAMs, creating an immunosuppressive TME.
bioRxiv · Dec 20, 2021Cancer Biology