Author

L. Wiedmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Assay:bulk RNA-seq· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:statistical model· 2

Frequent Co-Authors

A. Fischer· 4 shared J. Rodriguez-Vita· 4 shared F. De Angelis Rigotti· 3 shared I. Moll· 3 shared A. Trumpp· 2 shared E. Alsina-Sanchis· 2 shared G. Wolff· 2 shared M. Vacca· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersCancer Biology

A. Fischer

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

HAPLN1 is a driver for peritoneal carcinomatosis in pancreatic cancer

L. Wiedmann, F. De Angelis Rigotti, N. Vaquero-Siguero, E. Donato, E. Espinet, I. Moll, E. Alsina-Sanchis, R. Mülfarth, M. Vacca, J. Gerwing, A. Trumpp, A. Fischer, J. Rodriguez-Vita

This study identifies HAPLN1 as a driver of peritoneal metastasis in pancreatic cancer by enhancing tumor cell plasticity and immunomodulation.

bioRxiv · May 30, 2022Cancer Biology

Endothelial Rbpj is essential for the education of tumour-associated macrophages

R. Mülfarth, E. Alsina-Sanchis, I. Moll, S. Böhn, L. Wiedmann, L. Jordana Urriza, T. Ziegelbauer, J. Taylor, F. De Angelis Rigotti, A. Stögbauer, B. D. Giaimo, A. Cerwenka, T. Borggrefe, A. Fischer, J. Rodriguez-Vita

This study shows that endothelial Rbpj promotes TAM education in EOC by regulating CXCL2, which drives CD44 expression and cholesterol depletion in TAMs, creating an immunosuppressive TME.

bioRxiv · Dec 20, 2021Cancer Biology

Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function

G. Wolff, M. Sakurai, A. Mhamane, A. Maida, I. K. Deligiannis, K. Yin, P. Weber, A. Weider, M. Troullinaki, A. Zeigerer, M. Roden, N. Volk, T. Poth, T. Hackert, L. Wiedmann, , S. Herzig

This study shows that deleting TSC22D4 in hepatocytes reduces liver damage in NASH by improving mitochondrial function and lipid metabolism.

bioRxiv · Dec 17, 2021Physiology

Semaphorin 3C exacerbates liver fibrosis

F. De Angelis Rigotti, L. Wiedmann, M. O. Hubert, M. Vacca, S. S. Hasan, I. Moll, S. Carvajal, W. Jimenez, M. Starostecka, A. T. Billeter, B. Müller-Stich, G. Wolff, B. Ekim-Üstünel, S. Herzig, C. Mogler, , J. Rodriguez-Vita

This study identifies SEMA3C as a key driver of liver fibrosis by enhancing TGF-β signaling in hepatic stellate cells.

bioRxiv · Jul 29, 2021Pathology

CXCR3-expressing metastasis-initiating cells induce and exploit a fibroblast niche in the lungs to fuel metastatic colonization

M. Pein, J. Insua-Rodriguez, J. Meier, T. Hongu, L. Wiedmann, M. A. G. Essers, H.-P. Sinn, S. Spaich, M. Sutterlin, A. Schneeweiss, A. Trumpp, T. Oskarsson

This study identifies CXCR3-expressing breast cancer cells that induce fibroblast production of CXCL9/10 via IL-1 and JNK signaling, promoting metastatic colonization in the lungs.

bioRxiv · Feb 11, 2019Cancer Biology