V. Arumugaswami

Comparative Analysis of Molecular Pathogenic Mechanisms and Antiviral Development Targeting Old and New World Hantaviruses

This study compares molecular mechanisms and antiviral targets of Old and New World hantaviruses using human cell models and identifies potential therapeutic compounds.

ENDO-LYSOSOME-TARGETED NANOPARTICLE DELIVERY OF ANTIVIRAL THERAPY FOR CORONAVIRUS INFECTIONS

This study develops lysosome-targeted nanoparticles loaded with mefloquine to inhibit coronavirus infection, showing effectiveness against SARS-CoV-2 and its variants in cell models.

Broad-spectrum antiviral inhibitors targeting pandemic potential RNA viruses

This study identifies broad-spectrum antiviral agents effective against multiple RNA virus families, including arboviruses and respiratory pathogens.

Identification of a Papain-Like Protease Inhibitor with Potential for Repurposing in Combination with an Mpro Protease Inhibitor for Treatment of SARS-CoV-2

The paper identifies eltrombopag as a PLpro inhibitor that can be repurposed for SARS-CoV-2 treatment, effective in combination with Mpro inhibitors.

Hippo Signaling Pathway Activation during SARS-CoV-2 Infection Contributes to Host Antiviral Response

This study identifies Hippo signaling pathway activation as an antiviral response to SARS-CoV-2 infection and shows pharmacological targeting of the pathway can reduce virus replication.

Mitoquinone mesylate targets SARS-CoV-2 infection in preclinical models

Mitoquinone mesylate shows antiviral and anti-inflammatory effects against SARS-CoV-2 in preclinical models.

ORAI1 establishes resistance to SARS-CoV-2 infection by regulating tonic type I interferon signaling

This study shows ORAI1 regulates baseline type I interferon signaling, affecting resistance to SARS-CoV-2 infection.

Antiviral Drug Screen of Kinase inhibitors Identifies Cellular Signaling Pathways Critical for SARS-CoV-2 Replication

This study screens kinase inhibitors to identify compounds that block SARS-CoV-2 replication by targeting key cellular signaling pathways.

A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro

This paper shows that an anti-SEB monoclonal antibody inhibits SARS-CoV-2 entry by blocking protease access to the Spike protein's cleavage site.

Direct exposure to SARS-CoV-2 and cigarette smoke increases infection severity and alters the stemcell-derived airway repair response

This study shows that cigarette smoke exposure increases SARS-CoV-2 infection severity in airway cultures by reducing interferon response and ABSC proliferation.

SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery

The paper develops a primary human lung epithelium infection model to study SARS-CoV-2 pathobiology and screen drugs for COVID-19.

Human iPSC-Derived Cardiomyocytes are Susceptible to SARS-CoV-2 Infection

This study shows SARS-CoV-2 can infect human iPSC-derived cardiomyocytes in vitro, causing apoptosis and loss of beating, and establishes a model for studying infection mechanisms and drug screening.

Insights into Cross-species Evolution of Novel Human Coronavirus SARS-CoV-2 and Defining Immune Determinants for Vaccine Development

This study analyzes the evolution of SARS-CoV-2 and identifies immune determinants for vaccine development by examining mutational changes and T-cell epitopes across viral proteins.

High-throughput fitness profiling of Zika virus E protein reveals different roles for N-linked glycosylation during infection of mammalian and mosquito cells

This study identifies the role of N-linked glycosylation in ZIKV E protein function across mosquito and human cells using a mutant library.