Toxic Small Alarmone Synthetase FaRel2 inhibits translation by pyrophosphorylating tRNAGly and tRNAThr
Tatsuaki Kurata, Masaki Takegawa, Takayuki Ohira, Egor A. Syroegin, Gemma Catherine Atkinson, M. J. O. Johansson, Yury S. Polikanov, Abel García-Pino, Tsutomu Suzuki, Vasili Hauryliuk
The paper shows FaRel2, a toxSAS, specifically targets tRNAGly and tRNAThr by recognizing the acceptor stem, with structural differences explaining specificity variations among toxSASs.
Science Advances · Nov 13, 2024Peer-reviewedMicrobiology