Author

Abel García-Pino

Université Libre de BruxellesORCID 0000-0002-0634-0300Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:cell type annotation· 2 Organism:E. coli· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Assay:metagenomics· 1

Frequent Co-Authors

Vasili HauryliukiD· 4 shared Chloé MartensiD· 3 shared Kyo Coppieters ’t WallantiD· 3 shared Tatsuaki KurataiD· 3 shared Ariel Talavera· 2 shared Gemma Catherine AtkinsoniD· 2 shared Hedvig TammaniD· 2 shared Katleen Van NeromiD· 2 shared

Activity by Year

2019-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersMicrobiology

Vasili HauryliukORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Nanobody-mediated modulation of long RSH enzymes Rel and RelA catalysis by restriction of their conformational landscape

Katleen Van Nerom, Andres Ainelo, Kyo Coppieters ’t Wallant, Ariel Talavera, Dannele Echemendia-Blanco, Sarah Peeters, Brahim El Khalfaoui Oulali, Hedvig Tamman, Tatsuaki Kurata, Mohammad Roghanian, Chloé Martens, Els Pardon, Jan Steyaert, Vasili Hauryliuk, Abel García-Pino

This study identifies nanobodies that modulate Rel and RelA enzyme activity by trapping them in specific conformational states, inhibiting (p)ppGpp synthesis and affecting bacterial virulence.

bioRxiv · Aug 7, 2025 · PreprintMicrobiology

Toxic Small Alarmone Synthetase FaRel2 inhibits translation by pyrophosphorylating tRNAGly and tRNAThr

Tatsuaki Kurata, Masaki Takegawa, Takayuki Ohira, Egor A. Syroegin, Gemma Catherine Atkinson, M. J. O. Johansson, Yury S. Polikanov, Abel García-Pino, Tsutomu Suzuki, Vasili Hauryliuk

The paper shows FaRel2, a toxSAS, specifically targets tRNAGly and tRNAThr by recognizing the acceptor stem, with structural differences explaining specificity variations among toxSASs.

Science Advances · Nov 13, 2024Peer-reviewedMicrobiology

A versatile bacterial innate immunity protein directly senses two disparate phage proteins

Tong Zhang, Albinas Čepauskas, Anastasiia Nadieina, Aurélien Thureau, Kyo Coppieters ’t Wallant, Chloé Martens, Daniel Lim, Abel García-Pino, Michael T. Laub

This study shows that the bacterial immunity protein CapRelSJ46 can sense two distinct phage proteins using the same domain, highlighting its versatility in anti-phage defense.

Nature · Oct 16, 2024Peer-reviewedMicrobiology

Mechanism of phage sensing and abortion by toxin-antitoxin-chaperone systems

Toomas Mets, Tatsuaki Kurata, Karin Ernits, M. J. O. Johansson, Sophie Z. Craig, Gabriel Medina Evora, Jessica A. Buttress, Roni Odai, Kyo Coppieters ’t Wallant, Jose Alberto Nakamoto, Lena Shyrokova, Artyom A. Egorov, Christopher R. Doering, Tetiana Brodiazhenko, Michael T. Laub, , Vasili Hauryliuk

This study identifies and characterizes two Escherichia coli TAC systems that mediate antiphage defense by recognizing phage proteins and modifying mRNA to inhibit translation.

Cell Host & Microbe · May 30, 2024Peer-reviewedMicrobiology

Nucleotide-mediated allosteric regulation of bifunctional Rel enzymes

Hedvig Tamman, Katleen Van Nerom, Hiraku Takada, Niels Vandenberk, Daniel Scholl, Yury S. Polikanov, Johan Hofkens, Ariel Talavera, Vasili Hauryliuk, Jelle Hendrix, Abel García-Pino

This study reveals a guanosine-switch mechanism that regulates the opposing activities of bifunctional Rel enzymes through allosteric changes.

bioRxiv · Jun 13, 2019 · PreprintMolecular Biology