Author

Tatsuaki Kurata

Lund UniversityORCID 0000-0001-5986-7141Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:E. coli· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Assay:metagenomics· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Vasili HauryliukiD· 4 shared Abel García-PinoiD· 3 shared Gemma Catherine AtkinsoniD· 3 shared M. J. O. JohanssoniD· 3 shared Artyom A. EgoroviD· 2 shared Chloé MartensiD· 2 shared Karin ErnitsiD· 2 shared Kyo Coppieters ’t WallantiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersMicrobiology

Vasili HauryliukORCID

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4 papers

Recent·Most cited

Characterization of five environmental phages infecting Escherichia coli K-12 isolated during a phage biology training course

Lena Shyrokova, Artyom A. Egorov, Astrid Cole, Julián J. Duque-Pedraza, Anu Tyagi, Karin Ernits, Toomas Mets, Tatsuaki Kurata, J. Juozapaitis, Alessio Ling Jie Yang, Rodrigo Ibarra Chavez, Frederik Oskar Graversgaard Henriksen, Swenja Lassen, Gemma Catherine Atkinson, Vasili Hauryliuk, Marcus Johansson

The paper isolates and characterizes five Escherichia coli phages, identifies their defense system sensitivities, and highlights the educational value of phage isolation training.

Microbiology Spectrum · Nov 6, 2025Peer-reviewedMicrobiology

Nanobody-mediated modulation of long RSH enzymes Rel and RelA catalysis by restriction of their conformational landscape

Katleen Van Nerom, Andres Ainelo, Kyo Coppieters ’t Wallant, Ariel Talavera, Dannele Echemendia-Blanco, Sarah Peeters, Brahim El Khalfaoui Oulali, Hedvig Tamman, Tatsuaki Kurata, Mohammad Roghanian, Chloé Martens, Els Pardon, Jan Steyaert, Vasili Hauryliuk, Abel García-Pino

This study identifies nanobodies that modulate Rel and RelA enzyme activity by trapping them in specific conformational states, inhibiting (p)ppGpp synthesis and affecting bacterial virulence.

bioRxiv · Aug 7, 2025 · PreprintMicrobiology

Toxic Small Alarmone Synthetase FaRel2 inhibits translation by pyrophosphorylating tRNAGly and tRNAThr

Tatsuaki Kurata, Masaki Takegawa, Takayuki Ohira, Egor A. Syroegin, Gemma Catherine Atkinson, M. J. O. Johansson, Yury S. Polikanov, Abel García-Pino, Tsutomu Suzuki, Vasili Hauryliuk

The paper shows FaRel2, a toxSAS, specifically targets tRNAGly and tRNAThr by recognizing the acceptor stem, with structural differences explaining specificity variations among toxSASs.

Science Advances · Nov 13, 2024Peer-reviewedMicrobiology

Mechanism of phage sensing and abortion by toxin-antitoxin-chaperone systems

Toomas Mets, Tatsuaki Kurata, Karin Ernits, M. J. O. Johansson, Sophie Z. Craig, Gabriel Medina Evora, Jessica A. Buttress, Roni Odai, Kyo Coppieters ’t Wallant, Jose Alberto Nakamoto, Lena Shyrokova, Artyom A. Egorov, Christopher R. Doering, Tetiana Brodiazhenko, Michael T. Laub, , Vasili Hauryliuk

This study identifies and characterizes two Escherichia coli TAC systems that mediate antiphage defense by recognizing phage proteins and modifying mRNA to inhibit translation.

Cell Host & Microbe · May 30, 2024Peer-reviewedMicrobiology