Cancer BiologybioRxivPreprint
The Immune-Modulatory Function of Megakaryocytes in the Hematopoietic Niche of Myeloproliferative Neoplasms
Sandy Lee, Xiaoxi Yang, Kyla Masarik…·Huichun Zhan
This study shows that JAK2V617F mutant megakaryocytes drive immune dysregulation and HSC expansion in MPNs by reprogramming the marrow microenvironment and activating LINE-1 retrotransposons.
DOI 10.1101/2025.04.01.646152