Senataxin loss induces cGAS–STING-mediated mitochondrial dysfunction
Judith L.A. Fishburn, Hongchang Zhao, William Fosselman, Julian Flores, Megan Wong, Tamira Singh, Steven Q. Chen, Jacqueline H. Barlow
This study shows that Senataxin loss leads to mitochondrial dysfunction via the cGAS-STING pathway in both mouse cells and AOA2 patient cells.
bioRxiv · Jun 27, 2026 · PreprintCell Biology