Jacqueline H. Barlow

Distal super-enhancer drives aberrant CXCL13 expression in Cancer cells driving growth and p53 dysregulation via CXCR5-CXCL13 axis

This study identifies a distal super-enhancer near CCNG2 that drives aberrant CXCL13 expression in cancer cells, leading to growth promotion and p53 dysregulation via the CXCR5-CXCL13 axis.

Integrative proteomic analysis and molecular dynamics simulations of ANKLE2 reveal mechanisms of microcephaly

The paper uses proteomic analysis and molecular dynamics simulations to uncover how ANKLE2 mutations disrupt protein interactions and phosphorylation, leading to microcephaly.

Senataxin loss induces cGAS–STING-mediated mitochondrial dysfunction

This study shows that Senataxin loss leads to mitochondrial dysfunction via the cGAS-STING pathway in both mouse cells and AOA2 patient cells.

Reduced B cell activation in Germinal center reaction of the mouse model of Li-Fraumeni syndrome

This study shows that p53 mutations in Li-Fraumeni syndrome mice reduce B cell activation during germinal center reactions without affecting the ratio of activated B cells in dark and light zones.

G-quadruplex stabilization induces DNA breaks in pericentromericrepetitive DNA sequences in B lymphocytes

This study shows that G4-stabilizing drugs like pyridostatin cause DNA breaks and chromosomal rearrangements in B cells, with differential effects between primary and malignant cells.

DNA replication stress-induced transcriptome of Human Burkitt lymphoma identifies MBD1 as a novel suppressor of BCL6 rearrangements in germinal center derived B-lymphomagenesis

This study identifies MBD1 as a suppressor of BCL6 rearrangements in Burkitt lymphoma by regulating DNA methylation and genomic stability during DNA replication stress.

Stress Induced Signaling Pathways in Burkitt Lymphoma Play Novel Mechanisms in Fate Determination and Pathogenesis of Germinal Center-Derived B-Lymphomas

The paper investigates how stress-induced signaling pathways in Burkitt lymphoma affect B cell fate and lymphoma pathogenesis by analyzing gene regulation and transcriptional changes.

Genomic patterns of transcription-replication interactions in mouse primary B cells

The paper introduces TRIPn-Seq to identify transcription-replication interactions in mouse B cells, finding they correlate with replication stress and genomic instability.