Steven Q. Chen

Methodological Impacts on Microbiome Structure and Indicator Status in the Human Lower Respiratory Tract

This study evaluates how respiratory tract sampling methods affect inferred microbiome structure and identifies bronchial brushing as yielding a distinct but low-biomass microbial signal.

ASPIRE: the Amplicon Sequencing Profiler for Investigating Respiratory Ecosystems

ASPIRE processes and analyzes linked ASV-VOC data from respiratory microbiome studies to enable scalable comparative analysis and standardized file outputs.

Senataxin loss induces cGAS–STING-mediated mitochondrial dysfunction

This study shows that Senataxin loss leads to mitochondrial dysfunction via the cGAS-STING pathway in both mouse cells and AOA2 patient cells.

EpigeneticAgePipeline: an R package for comprehensive assessment of epigenetic age metrics from methylation microarrays

EpigeneticAgePipeline is an R package that estimates various epigenetic age metrics from methylation microarrays, offering quality control, preprocessing, and visualization tools.