Transcriptional reprogramming by IL-2 variant generates metabolically active stem-like T cells
Yaquelin Ortiz-Miranda, María Masid, Cristina Jiménez‐Luna, Galia Montalvo, Tania Muller, Nicolas Rayroux, Elisabetta Cribioli, Jesús Corría-Osorio, Helen Carrasco Hope, Romain Vuillefroy de Silly, Bili Seijo, Pierpaolo Ginefra, Kalet León, Nicola Vannini, Ping‐Chih Ho, , George Coukos
This study shows that a variant of IL-2 (IL-2v) induces a stem-like, metabolically active T-cell state with improved therapeutic potential in adoptive cell therapy.
bioRxiv · May 24, 2023 · PreprintSystems Biology