Functional and molecular rescue of aganglionic colon by human enteric nervous system progenitor transplantation in Hirschsprung disease
Benjamin Jevans, Fay Cooper, Luca Peruzza, Silvia Perin, Shuqi Li, Tara McAteer, Paolo De Coppi, Peter W. Andrews, Anestis Tsakiridis, Conor J. McCann
This study demonstrates that transplanting human pluripotent stem cell-derived enteric nervous system progenitors can improve contractile function and rescue molecular pathways in Hirschsprung disease colonic tissue.
bioRxiv · Oct 16, 2025 · PreprintCell Biology