Fay Cooper

This study shows Notch signalling regulates human ENS progenitor dynamics, affecting differentiation and migration, and links its disruption to intestinal aganglionosis.

This study demonstrates that transplanting human pluripotent stem cell-derived enteric nervous system progenitors can improve contractile function and rescue molecular pathways in Hirschsprung disease colonic tissue.

This study generates fam83f knock-out zebrafish to investigate Fam83f's role in hatching and DNA damage response, finding impaired autophagy and increased radiation sensitivity.

This study shows Notch signalling promotes mesodermal fate and HOX gene activation in human NMPs while inhibiting neural fate through a feedback loop with FGF.

This study generates and characterizes human pre-neural spinal cord progenitors that can self-renew and differentiate into neural crest cells while adopting rostrocaudal identities.