Anestis Tsakiridis

Notch signalling governs human enteric nervous system progenitor dynamics

This study shows Notch signalling regulates human ENS progenitor dynamics, affecting differentiation and migration, and links its disruption to intestinal aganglionosis.

Dynamic modelling of human neural crest development using a bioengineered stem cell organoid system

This paper introduces a bioengineered stem cell organoid system to model human neural crest development, showing it recapitulates key developmental dynamics and can be used for cross-species validation.

Generation of human hindlimb/genital tubercle progenitors from pluripotent stem cells

This study generates human hindlimb/genital tubercle progenitors from pluripotent stem cells using WNT-FGF-BMP signaling and shows their developmental potency through xenografting.

Functional and molecular rescue of aganglionic colon by human enteric nervous system progenitor transplantation in Hirschsprung disease

This study demonstrates that transplanting human pluripotent stem cell-derived enteric nervous system progenitors can improve contractile function and rescue molecular pathways in Hirschsprung disease colonic tissue.

Notch signalling influences cell fate decisions and HOX gene induction in axial progenitors

This study shows Notch signalling promotes mesodermal fate and HOX gene activation in human NMPs while inhibiting neural fate through a feedback loop with FGF.

Early anteroposterior regionalisation of human neural crest is shaped by a pro-mesodermal factor

This study identifies TBXT's role in early posterior regionalisation of human neural crest cells through chromatin remodelling and WNT signalling.

Defining the signalling determinants of a posterior ventral spinal cord identity in human neuromesodermal progenitor derivatives

This study identifies signalling pathways that guide the generation of posterior ventral spinal cord motor neurons from human pluripotent stem cells.

Retinoic acid accelerates the specification of enteric neural progenitors from in vitro-derived neural crest

This study shows retinoic acid accelerates the generation of enteric neural progenitors from human pluripotent stem cells, which can form enteric neurons and colonize the ENS in mice.

Human axial progenitors generate trunk neural crest cells

This study identifies that human axial progenitors generate trunk neural crest cells and defines their molecular signatures.