Author

Taylor Smith

Trinity College Dublin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Aisling Y. CoughlaniD· 1 shared Anthony M. McElligottiD· 1 shared Diego PasiniiD· 1 shared Emma J. DoyleiD· 1 shared Eric ConwayiD· 1 shared Eugène DilloniD· 1 shared Maeve BoyceiD· 1 shared Nina M. OrfaliiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperGenetics

Aisling Y. CoughlanORCID

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1 paper

Recent·Most cited

Divergent Pathogenic PR-DUB Complex Variants Converge Functionally Via PRC2 Displacement From Chromatin

Emma J. Doyle, Maeve Boyce, Sarah Buggle, Taylor Smith, Eugène Dillon, Anthony M. McElligott, Nina M. Orfali, Aisling Y. Coughlan, Diego Pasini, Eric Conway

The paper shows that pathogenic PR-DUB complex variants reduce H2AK119ub1 levels by stabilizing truncated ASXL1, leading to PRC2 displacement and H3K27me3 reduction, a phenotype shared across different chromatinopathies.

bioRxiv · Jul 26, 2026 · PreprintGenetics