Eric Conway

The paper shows that pathogenic PR-DUB complex variants reduce H2AK119ub1 levels by stabilizing truncated ASXL1, leading to PRC2 displacement and H3K27me3 reduction, a phenotype shared across different chromatinopathies.

This study identifies AEBP2 as a therapeutic target in EZH2-mutant lymphoma by showing its role in maintaining H3K27me2 levels through a PRC2.2 complex.

This study investigates EZH2 variants linked to Weaver syndrome, showing they cause dominant negative effects on H3K27 methylation, altering chromatin states and contributing to developmental disorders.

This study shows BAP1 regulates PcG occupancy and chromatin condensation by limiting H2AK119ub1 deposition, revealing its role in counteracting PCGF3/5-dependent PRC1 activity.

This study shows that H2AK119ub1 deposition is essential for maintaining PcG-target gene repression in ESCs by coordinating PRC1 and PRC2 activities.