Author

Diego Pasini

University of MilanORCID 0000-0002-9879-6486Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:ChIP-seq· 3 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Eric ConwayiD· 4 shared Daniel Fernández-PéreziD· 2 shared Daria ManganaroiD· 2 shared Marika ZanottiiD· 2 shared Simona RodighieroiD· 2 shared Simone TamburriiD· 2 shared Adrian P. BrackeniD· 1 shared Aisling Y. CoughlaniD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersGenetics

Eric ConwayORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Divergent Pathogenic PR-DUB Complex Variants Converge Functionally Via PRC2 Displacement From Chromatin

Emma J. Doyle, Maeve Boyce, Sarah Buggle, Taylor Smith, Eugène Dillon, Anthony M. McElligott, Nina M. Orfali, Aisling Y. Coughlan, Diego Pasini, Eric Conway

The paper shows that pathogenic PR-DUB complex variants reduce H2AK119ub1 levels by stabilizing truncated ASXL1, leading to PRC2 displacement and H3K27me3 reduction, a phenotype shared across different chromatinopathies.

bioRxiv · Jul 26, 2026 · PreprintGenetics

Dominant negative effects on H3K27 methylation by Weaver syndrome-associated EZH2 variants

Orla Deevy, Craig Monger, Francesca Matrà, Ellen Tuck, Eric Conway, Mihaly Badonyi, Darragh Nimmo, Simona Rodighiero, Qi Zhang, Chen Davidovich, Joseph A. Marsh, Diego Pasini, Adrian P. Bracken

This study investigates EZH2 variants linked to Weaver syndrome, showing they cause dominant negative effects on H3K27 methylation, altering chromatin states and contributing to developmental disorders.

bioRxiv · Jun 1, 2023 · PreprintGenetics

BAP1 activity regulates PcG occupancy and global chromatin condensation counteracting diffuse PCGF3/5-dependent H2AK119ub1 deposition

Eric Conway, Federico Rossi, Simone Tamburri, Eleonora Ponzo, Karin Johanna Ferrari, Marika Zanotti, Daniel Fernández-Pérez, Daria Manganaro, Simona Rodighiero, Diego Pasini

This study shows BAP1 regulates PcG occupancy and chromatin condensation by limiting H2AK119ub1 deposition, revealing its role in counteracting PCGF3/5-dependent PRC1 activity.

bioRxiv · Dec 10, 2020 · PreprintMolecular Biology

Histone H2AK119 Mono-Ubiquitination is Essential for Polycomb-Mediated Transcriptional Repression

Simone Tamburri, Elisa Lavarone, Daniel Fernández-Pérez, Eric Conway, Marika Zanotti, Daria Manganaro, Diego Pasini

This study shows that H2AK119ub1 deposition is essential for maintaining PcG-target gene repression in ESCs by coordinating PRC1 and PRC2 activities.

Molecular Cell · Dec 26, 2019Peer-reviewedMolecular Biology