Author

Sarah Buggle

University College DublinORCID 0009-0003-1586-0775Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Aisling Y. CoughlaniD· 1 shared Anthony M. McElligottiD· 1 shared Diego PasiniiD· 1 shared Emma J. DoyleiD· 1 shared Eric ConwayiD· 1 shared Eugène DilloniD· 1 shared Maeve BoyceiD· 1 shared Nina M. OrfaliiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperGenetics

Aisling Y. CoughlanORCID

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1 paper

Recent·Most cited

GeneticsbioRxivPreprintJul 26, 2026

Divergent Pathogenic PR-DUB Complex Variants Converge Functionally Via PRC2 Displacement From Chromatin

Emma J. Doyle, Maeve Boyce, Sarah Buggle…·Eric Conway

The paper shows that pathogenic PR-DUB complex variants reduce H2AK119ub1 levels by stabilizing truncated ASXL1, leading to PRC2 displacement and H3K27me3 reduction, a phenotype shared across different chromatinopathies.

DOI 10.64898/2026.07.23.740410

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