Aspartate Transaminases Are Dispensable for Pancreatic Development and Pancreatic Cancer Progression
Julia Ugras, Noah S. Nelson, Samuel A. Kerk, Damien Sutton, Lin Lin, Peter Sajjakulnukit, Teresa Dombrowski, Gillian Davidson, Brooke L. Lavoie, Dominik Awad, Alberto Olivei, Wei Yan, Christopher L. Strayhorn, Megan D. Radyk, Matthew D. Perricone, , Costas Andreas Lyssiotis
This study investigates the role of aspartate transaminases in pancreatic development and cancer progression using conditional knockout mice, finding that their loss does not affect tumor growth but impacts pancreas size in double knockout models.
bioRxiv · Dec 19, 2025 · PreprintCancer Biology