Filip Bednar

The paper analyzes matched pre- and post-chemotherapy biospecimens in pancreatic cancer, revealing that cancer-associated fibroblasts undergo neural reprogramming, characterized by axonal guidance gene enrichment, which may contribute to chemoresistance and tumor progression.

The paper identifies a KRT17-positive, low-grade epithelial population in IPMNs with malignant features using spatial transcriptomics and single-cell RNA sequencing.

This study investigates the role of aspartate transaminases in pancreatic development and cancer progression using conditional knockout mice, finding that their loss does not affect tumor growth but impacts pancreas size in double knockout models.

This study shows DUSP6 is upregulated in pancreatic cancer metastasis and independently influences cell migration and metabolism, suggesting it as a therapeutic target.

This study identifies ROR2 as a regulator of cellular plasticity in pancreatic neoplasia, showing it promotes an aggressive PDAC phenotype and resistance to KRAS inhibitors.