Author

Megan D. Radyk

University of MichiganORCID 0000-0002-3660-2906Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:imaging· 1

Frequent Co-Authors

Alberto Olivei· 1 shared Brooke L. Lavoie· 1 shared Christopher L. Strayhorn· 1 shared Costas Andreas LyssiotisiD· 1 shared Damien Sutton· 1 shared Dominik AwadiD· 1 shared Filip BednariD· 1 shared Gabriel Anthony Nicolazzi· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

Alberto Olivei

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Aspartate Transaminases Are Dispensable for Pancreatic Development and Pancreatic Cancer Progression

Julia Ugras, Noah S. Nelson, Samuel A. Kerk, Damien Sutton, Lin Lin, Peter Sajjakulnukit, Teresa Dombrowski, Gillian Davidson, Brooke L. Lavoie, Dominik Awad, Alberto Olivei, Wei Yan, Christopher L. Strayhorn, Megan D. Radyk, Matthew D. Perricone, , Costas Andreas Lyssiotis

This study investigates the role of aspartate transaminases in pancreatic development and cancer progression using conditional knockout mice, finding that their loss does not affect tumor growth but impacts pancreas size in double knockout models.

bioRxiv · Dec 19, 2025 · PreprintCancer Biology

Cathartocytosis: Jettisoning of Unwanted Material during Cellular Reprogramming

Jeffrey Wade Brown, Xiaobo Lin, Gabriel Anthony Nicolazzi, Xuemei Liu, Thanh Nguyen, Megan D. Radyk, Joseph Burclaff, Jason C. Mills

The paper describes a novel lysosome-independent process called cathartocytosis, where cells eject unwanted material during reprogramming, distinct from autophagy.

Cell Reports · Jul 30, 2025Peer-reviewedCell Biology