Teresa Saez

Mixed positive and negative feedback loops drive diverse single-cell gene expression dynamics

The paper uses stochastic modeling and experiments to show mixed feedback loops in bacteria generate diverse gene expression dynamics.

Environmental and molecular noise buffering by the cyanobacterial clock in individual cells

The paper shows how the cyanobacterial clock buffers noise through its core phosphorylation loop, using single-cell analysis and a stochastic model.

The alternative sigma factor RpoD4 pulses at division and links the circadian clock and the cell cycle in Synechococcus elongatus

This study uses single-cell time-lapse microscopy to show that RpoD4 pulses at cell division and links the circadian clock and cell cycle in Synechococcus elongatus.

Tunable phenotypic variability through an autoregulatory alternative sigma factor circuit

The paper shows that the σV circuit in B. subtilis generates tunable phenotypic variability in response to stress, memory of previous stress, and genetic perturbations.

Synergy with TGFβ ligands switches WNT pathway dynamics from transient to sustained during human pluripotent cell differentiation

The paper investigates how TGFβ ligands alter WNT/{beta}-catenin signaling dynamics during human pluripotent cell differentiation, showing a shift from transient to sustained responses.