Multiple long-range cis interactions generate CTCF insulator-dependent viral chromatin domains in quiescent HSV-1 genomes
Alyssa R. Richman, Sophie Kogut, Terri G. Edwards, Joseph R. Boyd, Princess D. Rodriguez, Michael Mariani, Mason A. Shipley, Kayley A. Manuel, Ziyun A. Ye, David C. Bloom, Seth E. Frietze, Donna M. Neumann
The paper investigates how HSV-1 CTCF insulators regulate chromatin organization and transcription through long-range cis interactions, showing that deletion of the CTRL2 insulator disrupts chromatin domains and alters transcriptional accessibility.
mBio · Aug 28, 2025Peer-reviewedMicrobiology