Author

David C. Bloom

University of FloridaORCID 0000-0001-5935-8494Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:Hi-C· 1 Approach:statistical model· 1 Organism:virus· 1

Frequent Co-Authors

Donna M. NeumanniD· 2 shared Mason A. ShipleyiD· 2 shared Alyssa R. RichmaniD· 1 shared Jasbir Singh· 1 shared Joseph R. BoydiD· 1 shared Kayley A. Manuel· 1 shared Michael MarianiiD· 1 shared Princess D. RodrigueziD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersMicrobiology

Donna M. NeumannORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintOct 14, 2026

AAV-Mediated Ribozyme Targeting of HSV-1 Latency-Associated Transcript RNAs Reveals Distinct Functions of the LAT Intron and Exon In Vivo

Mason A. Shipley, Jasbir Singh, David C. Bloom, Donna M. Neumann

This study uses ribozymes to target HSV-1 LAT RNA components in vivo, revealing distinct roles of the LAT intron and exon in latency and reactivation.

DOI 10.64898/2026.10.13.758874

experimental assay

𝕏 PostBluesky

MicrobiologymBioPeer-reviewedAug 28, 2025

Multiple long-range cis interactions generate CTCF insulator-dependent viral chromatin domains in quiescent HSV-1 genomes

Alyssa R. Richman, Sophie Kogut, Terri G. Edwards…·Donna M. Neumann

The paper investigates how HSV-1 CTCF insulators regulate chromatin organization and transcription through long-range cis interactions, showing that deletion of the CTRL2 insulator disrupts chromatin domains and alters transcriptional accessibility.

3 citations

virusHi-C

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