Author

Sophie Kogut

Fred Hutch Cancer CenterORCID 0000-0003-4537-7584Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:Hi-C· 1 Organism:human· 1

Frequent Co-Authors

Alyssa R. RichmaniD· 1 shared Brad R. RosenbergiD· 1 shared Daniel Blanco-MeloiD· 1 shared David C. BloomiD· 1 shared Donna M. NeumanniD· 1 shared Joseph R. BoydiD· 1 shared Julie EggenbergeriD· 1 shared Kayley A. Manuel· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMicrobiology

Alyssa R. RichmanORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintMar 27, 2026

Pluripotency Factors Modulate Interferon Signaling in Embryonic Stem Cells

Qing Yang, Mónica Padilla-Gálvez, Skyler A. Uhl…·Daniel Blanco-Melo

This study shows that pluripotency factors in hESCs regulate negative interferon regulators, suppressing interferon signaling to maintain pluripotency while preserving antiviral resistance.

DOI 10.64898/2026.03.23.713714

humanscRNA-seq

𝕏 PostBluesky

MicrobiologymBioPeer-reviewedAug 28, 2025

Multiple long-range cis interactions generate CTCF insulator-dependent viral chromatin domains in quiescent HSV-1 genomes

Alyssa R. Richman, Sophie Kogut, Terri G. Edwards…·Donna M. Neumann

The paper investigates how HSV-1 CTCF insulators regulate chromatin organization and transcription through long-range cis interactions, showing that deletion of the CTRL2 insulator disrupts chromatin domains and alters transcriptional accessibility.

3 citations

virusHi-C

𝕏 PostBluesky