Mason A. Shipley

AAV-Mediated Ribozyme Targeting of HSV-1 Latency-Associated Transcript RNAs Reveals Distinct Functions of the LAT Intron and Exon In Vivo

This study uses ribozymes to target HSV-1 LAT RNA components in vivo, revealing distinct roles of the LAT intron and exon in latency and reactivation.

The HSV-1 LAT enhancer regulates locus-specific H3.1 enrichment during early lytic infection

The paper identifies the HSV-1 LAT enhancer's role in regulating H3.1 histone enrichment at specific lytic genes during early infection.

In HSV-1, the LAT Enhancer Drives Pre-IE VP16 Transcription to Initiate Reactivation

This paper shows that the LAT enhancer drives VP16 transcription during HSV-1 reactivation, overcoming CTCF and cohesin-mediated silencing during latency.

Multiple long-range cis interactions generate CTCF insulator-dependent viral chromatin domains in quiescent HSV-1 genomes

The paper investigates how HSV-1 CTCF insulators regulate chromatin organization and transcription through long-range cis interactions, showing that deletion of the CTRL2 insulator disrupts chromatin domains and alters transcriptional accessibility.