Nuclear ASC speck formation in microglia is associated with inflammasome priming and is exacerbated in LRRK2-G2019S Parkinson disease
Luca Ballotto, Thomas Baratta, Helena Winterberg, Cédric Dusanter, Sara Sambin, Jean‐Christophe Corvol, Ludovica Iovino, Luigi Bubacco, Olga Corti, Elisa Greggio, Salvatore Novello
This study shows that LRRK2-G2019S mutation in microglia increases nuclear ASC speck formation, indicating a primed inflammasome state linked to chronic neuroinflammation in Parkinson's disease.
Neurobiology of Disease · Dec 25, 2025Peer-reviewedPhysiology