Luigi Bubacco

This study shows that evolutionary divergence in LRRK2 interaction domains leads to species-specific protein interaction networks in humans and mice.

This study shows that DJ-1 deficiency impairs autophagosome-lysosome fusion and lysosomal degradation, leading to autophagic substrate accumulation through ROS-dependent modulation of the AMPK/mTORC1 axis in Parkinson's disease.

This study shows that LRRK2-G2019S mutation in microglia increases nuclear ASC speck formation, indicating a primed inflammasome state linked to chronic neuroinflammation in Parkinson's disease.

This study identifies PAK6 as a modifier of LRRK2 mutations, showing it rescues ciliogenesis defects in G2019S but not R1441C mutations.

This study quantifies PAK6 and 14-3-3 gamma in plasma to assess their potential as biomarkers for diagnosing sporadic and LRRK2-linked Parkinson's disease.

This study shows that the LRRK2 G2019S mutation impairs EAAT2 trafficking, leading to reduced glutamate clearance and potential neurodegeneration in Parkinson's disease.

This study shows DOPAL promotes αSynuclein accumulation and impairs proteostasis in neuronal projections, contributing to Parkinson's disease progression.