Author

Luca Ballotto

University of PaduaORCID 0009-0007-5144-2246Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Elisa GreggioiD· 2 shared Luigi BubaccoiD· 2 shared Cédric DusanteriD· 1 shared Claudia ManzoniiD· 1 shared Francesco RaimondiiD· 1 shared Helena Winterberg· 1 shared Jean‐Christophe CorvoliD· 1 shared Ludovica IovinoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBioinformatics

Elisa GreggioORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintJul 21, 2026

Evolutionary divergence of LRRK2 interaction domains contributes to human- and mouse-specific protein interaction networks

Luca Ballotto, Pasquale Miglionico, Yibo Zhao…·Claudia Manzoni

This study shows that evolutionary divergence in LRRK2 interaction domains leads to species-specific protein interaction networks in humans and mice.

DOI 10.64898/2026.07.17.738869

𝕏 PostBluesky

PhysiologyNeurobiology of DiseasePeer-reviewedDec 25, 2025

Nuclear ASC speck formation in microglia is associated with inflammasome priming and is exacerbated in LRRK2-G2019S Parkinson disease

Luca Ballotto, Thomas Baratta, Helena Winterberg…·Salvatore Novello

This study shows that LRRK2-G2019S mutation in microglia increases nuclear ASC speck formation, indicating a primed inflammasome state linked to chronic neuroinflammation in Parkinson's disease.

3 citations

mouseexperimental assay

𝕏 PostBluesky