Author

Thomas Green

Broad InstitutePrimary ORCID profile (0009-0001-9559-8054 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Thomas GreeniD1 paper

Biology Disciplines

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Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Research Focus:software / tool· 1 Research Focus:variant calling· 1

Frequent Co-Authors

David E. RootiD· 2 shared Aaron C. WacholderiD· 1 shared Adam BrowniD· 1 shared Adam FrankishiD· 1 shared Alisa Potter· 1 shared Amy B. GoodaleiD· 1 shared Andrew J. AguirreiD· 1 shared Andrew Lee HongiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

David E. RootORCID

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Author profile →

2 papers

Recent·Most cited

High-quality peptide evidence for annotating non-canonical open reading frames as human proteins

Eric W. Deutsch, Leron W. Kok, Jonathan M. Mudge, Cristian Valls, Irwin Jungreis, Jorge Ruiz‐Orera, Zhi Sun, Ulrike Kusebauch, Ivo Fierro-Monti, Jennifer G. Abelin, M. Mar Albà, Julie L. Aspden, Sreejan Bandyopadhyay, Kaushik Banerjee, Pavel V. Baranov, , Sebastiaan van Heesch

The paper identifies 25% of 7,264 non-canonical open reading frames (ncORFs) as producing translated gene products, supported by over 3,000 peptides from 3.8 billion mass spectra.

Nature · May 6, 2026Peer-reviewedMolecular Biology

Defining protein variant functions using high-complexity mutagenesis libraries and enhanced mutant detection software ASMv1.0

Xiaoping Yang, Andrew Lee Hong, Ted Sharpe, Andrew O. Giacomelli, Robert E. Lintner, Douglas Alan, Thomas Green, Tikvah K. Hayes, Federica Piccioni, Briana Fritchman, Hinako Kawabe, Edith Sawyer, Luke Sprenkle, Benjamin P. Lee, Nicole S. Persky, , David E. Root

The paper introduces a method to screen large variant libraries with mutations across wide regions using improved mutant detection software, enabling accurate variant calling and counting from sequencing data.

bioRxiv · Jun 16, 2021 · PreprintSystems Biology