Julie L. Aspden

This paper demonstrates single-molecule nanopore sensing using a solid polymer electrolyte instead of liquid electrolytes, enhancing sensitivity and enabling robust, portable sensing platforms.

This study shows that ribosome specialisation in eukaryotes arises through constructive neutral evolution, not adaptation or selection.

The paper identifies 25% of 7,264 non-canonical open reading frames (ncORFs) as producing translated gene products, supported by over 3,000 peptides from 3.8 billion mass spectra.

This study identifies RNA-binding targets of the HOW(S) protein in Drosophila spermatogenesis using RIP-seq, revealing novel transcripts and motif preferences.

This study investigates how age and sex affect mRNA stability and polyadenylation in equine joint tissues, revealing sex-specific differences in transcript stability and age-related changes in polyadenylation site usage.

The paper expands and refines a reference catalog of human non-canonical open reading frames (ncORFs) by incorporating more datasets and introducing a translation signature score framework to prioritize high-quality ncORFs.

The paper examines translational activity of 80S monosomes in different Drosophila tissues, finding that head and embryo monosomes are active while testis and ovary monosomes are inactive.

This study shows that EMG1 methyltransferase activity regulates ribosome occupancy at KSHV uORFs, affecting viral protein expression and infectious virus production.

The paper examines 5' untranslated regions (UTRs) to show their role in translational regulation of dosage-sensitive genes and introduces a web tool for analyzing 5UTR composition.

The paper examines XIST RNA-protein interactions across mammals with different early pregnancy morphologies, finding conserved binding partners but species-specific binding preferences.

This paper outlines a community-driven initiative to create a consolidated catalog of human Ribo-seq ORFs, addressing the lack of standardized annotation for these features.

This study uses RNA-seq data to detect somatic variants and identify cancer drivers in 1,359 samples, showing RNA-seq can effectively replace WES/WGS for this task.

The paper identifies lncRNAs that interact with the translation machinery during neuronal differentiation and shows some produce peptides that affect neurite length.

The paper improves Poly-Ribo-Seq to study small ORF translation in Drosophila embryos, revealing both productive and non-productive ribosomal binding patterns across embryonic stages.