Author

Ted Sharpe

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:variant calling· 3 Organism:human· 2 Assay:whole-genome sequencing· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Approach:experimental assay· 1

Frequent Co-Authors

Matthew M. MeyersoniD· 2 shared Adam BrowniD· 1 shared Adolfo CorreaiD· 1 shared Alexander Baumann· 1 shared Amit V. KheraiD· 1 shared Andrea SaltzmaniD· 1 shared Andrew J. AguirreiD· 1 shared Andrew Lee HongiD· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersSystems Biology

Matthew M. MeyersonORCID

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3 papers

Recent·Most cited

Defining protein variant functions using high-complexity mutagenesis libraries and enhanced mutant detection software ASMv1.0

Xiaoping Yang, Andrew Lee Hong, Ted Sharpe, Andrew O. Giacomelli, Robert E. Lintner, Douglas Alan, Thomas Green, Tikvah K. Hayes, Federica Piccioni, Briana Fritchman, Hinako Kawabe, Edith Sawyer, Luke Sprenkle, Benjamin P. Lee, Nicole S. Persky, , David E. Root

The paper introduces a method to screen large variant libraries with mutations across wide regions using improved mutant detection software, enabling accurate variant calling and counting from sequencing data.

bioRxiv · Jun 16, 2021 · PreprintSystems Biology

An open resource of structural variation for medical and population genetics

Ryan L. Collins, Harrison Brand, Konrad J. Karczewski, Xuefang Zhao, Jessica Alföldi, Laurent C. Francioli, Amit V. Khera, Chelsea Lowther, Laura Doyle Gauthier, Harold Wang, Nicholas A. Watts, Matthew Solomonson, Anne O’Donnell‐Luria, Alexander Baumann, Ruchi Munshi, , Adolfo Correa

Short-read genome sequencing of 14,891 diverse genomes yields 433,371 structural variants (SVs) for gnomAD; loss-constrained genes also resist duplication, and clinical SV carrier rates are benchmarked.

Nature · May 27, 2020Peer-reviewedGenomics✦ In-depth digest

Genome-wide detection of structural variants and indels by local assembly

Jeremiah A. Wala, Pratiti Bandopadhayay, Noah F. Greenwald, Ryan O’Rourke, Ted Sharpe, Chip Stewart, Steven E. Schumacher, Yilong Li, Joachim Weischenfeldt, Xiaotong Yao, Chad Nusbaum, Peter J. Campbell, Gad A. Getz, Matthew M. Meyerson, Cheng‐Zhong Zhang, , Rameen Beroukhim

SvABA detects structural variants and indels using genome-wide local assembly, showing improved sensitivity and specificity, especially for small variants and complex rearrangements in cancer genomes.

Genome Research · Apr 1, 2018Peer-reviewedGenomics